Mutations are the real engine behind long-term stat growth in Mewgenics. While base stats and classes matter, mutations are what let you push your cats beyond normal limits. A well-managed mutation system can turn average kittens into powerful stat monsters across generations. This guide explains how mutations work, how to obtain them consistently, and how to build a breeding setup that maximizes your stats. Also check out our Mewgenics Beginner Guide for those interested!
What Mutations Do and Why They Matter
Mutations are special traits marked by a DNA icon. They can change stats, add passives, or create unique combat effects. Many mutations give direct stat bonuses like +2 to one attribute and -1 to another, which is often a net gain if you breed carefully.
Some mutations are even stronger and add special mechanics, such as projectile reflection or bonus scaling each turn. These traits can be inherited through breeding, making them the foundation of long-term stat optimization.
You can stack different mutation types across body parts like eyes, arms, legs, and fur to create highly specialized kittens.
All Main Ways to Get Mutations
Events During Runs
Special in-run events can permanently mutate your cat. These mutations often have strong effects and no major drawbacks. If you find a good mutation from an event, prioritize retiring and breeding that cat to spread the trait.
Mutation Items
Certain items can force mutations. One of the strongest strategies involves items that trigger mutations when a cat is downed in battle. A common approach is to run a fragile build that intentionally falls in combat while still helping the team.
Classes that function well at low health make this strategy safer. Even short farming runs can produce multiple mutated breeding candidates.
Stray Cats
Improving your home’s appeal increases the quality of stray cats that visit. Some strays arrive with built-in mutations or passives. These cats are valuable for introducing new genetic lines into your breeding pool.
Overnight Room Mutations
Rooms with high mutation stats can cause cats to evolve overnight. This is separate from breeding and adds random mutations directly. A dedicated mutation room can slowly generate new traits without risking your main breeding pairs.
All Mutation Stat & More:
Best Breeding Room Setup for Maximum Stats
Your breeding room should focus on two key stats:
- Comfort: Raises the chance cats will breed instead of fighting
- Stimulation: Improves kitten quality and mutation inheritance
Keep the room population small. Too many cats reduce comfort and hurt breeding efficiency. Use only your strongest mutated cats as breeding stock.
Mutation room stats are useful but separate. They increase overnight mutation chances, not inheritance rates. Many players run two rooms: one optimized for breeding and another stacked for mutation growth.
Avoid Inbreeding and Manage Lineage
Breeding close relatives increases the risk of negative mutations. While some bad traits can be situationally useful, stacking too many will weaken your bloodline.
Track family lines and rotate in outside genetics from strays when needed. Tools and upgrades that reveal hidden stats and lineage information make this process much easier and should be prioritized early.
Practical Steps to Start Optimizing Now
If you want immediate progress, follow this order:
- Identify cats that already have strong mutations
- Create a small, dedicated breeding room
- Stack comfort and stimulation furniture
- Farm runs specifically to obtain new mutations
- Use a separate mutation room for overnight evolution
- Introduce stray cats to refresh genetics
Starting with just two strong mutated parents is enough to build a powerful lineage over time.
Mutations are the fastest way to scale stats and power across generations. By farming event mutations, using mutation items wisely, and designing efficient breeding rooms, you can steadily produce stronger kittens with stacked bonuses. Once your system is running, each new generation becomes an upgrade over the last, giving you a reliable path toward high-stat teams and smoother future runs.