All Best Runes Sailor Piece Guide & How to Get Them!

Runes in Sailor Piece are technically optional—but if you care about PvP, boss damage, or late-game dungeon clears, they make a massive difference. The right rune can multiply your damage, increase survivability, or add powerful status effects. In this guide, you’ll find a full rune tier list, stat breakdowns (base and max upgrades), and the exact method to unlock them. Also check out our Sailor Piece Codes for more rewards!

Sailor Piece Rune Tier List (Ranked)

All Best Runes Sailor Piece Guide & How to Get Them!

Below is a performance-based ranking focused on real combat impact, not just rarity.

S-Tier Runes (Best Overall)

These runes offer the strongest scaling and highest value in both PvE and PvP.

Inferno Rune (Mythical)

One of the strongest damage-over-time options in the game.

• Base: 70% burn damage (scales with your damage stat)
• Max: 104% burn damage
• Duration: Several seconds

Inferno is ideal for DPS builds. The scaling makes it devastating in extended fights and boss battles.

Blood Rune (Mythical)

Another top-tier damage-over-time rune.

• Base: 65% blood damage over 5 seconds
• Max: 97% blood damage over 5 seconds
• Scales with damage stat

Blood Rune performs similarly to Inferno and is extremely strong for sustained damage builds.

Best For: PvP pressure, boss melting, high-DPS setups.

A-Tier Runes (Strong & Reliable)

Very powerful, but slightly more situational compared to S-tier.

Guardian Rune (Epic)

Excellent survivability option.

• Base: +39% Max HP (1.39x multiplier)
• Max: +59% Max HP (1.59x multiplier)

Guardian is massive for tank builds or difficult dungeon runs.

Wrath Rune (Mythical)

Pure damage scaling.

• Base: +40% damage
• Max: +59% damage (1.59x multiplier)

Wrath is one of the best raw damage boosters in the game. While it lacks burn or bleed effects, the multiplier alone makes it extremely competitive.

Best For: Burst builds and endgame scaling.

B-Tier Runes (Solid but Outclassed)

Useful in certain situations but not optimal for most builds.

Frost Rune (Legendary)

Provides crowd control.

• Base: Freezes enemies for 2 seconds + 30% impact damage
• Max: Freezes for 3 seconds + 44% impact damage

The freeze effect makes it valuable for controlling groups in dungeon waves.

Destruction Rune (Legendary)

A weaker damage multiplier.

• Base: +25% damage
• Max: +37% damage

Good early or mid-game option, but inferior to Wrath Rune in scaling.

C-Tier Rune (Minor Impact)

Suppression Rune (Rare)

Defensive but limited.

• Base: 10% damage reduction
• Max: 15% damage reduction

Helpful, but not game-changing compared to Guardian.

D-Tier Rune (Farming Only)

Fortune Rune (Mythical)

Luck-based utility.

• Base: +10% luck
• Max: +15% luck

Useful for farming drops, but it provides zero combat strength. Not recommended for serious PvP or boss fights.

How to Get Runes in Sailor Piece

The only way to obtain runes is by clearing the Rune Dungeon.

Step 1: Get a Dungeon Key

Before entering the Rune Dungeon, you need a Dungeon Key (Epic rarity). Dungeon keys drop from World Bosses (not guaranteed). Bosses that can drop keys include:

• Saber (Boss Island)
• Sukuna (Shabuya Station)
• Gojo (Shabuya Station)
• Yuji (Shabuya Station)
• SJW (Sailor Island)
• Aliard (Sailor Island)
• Ragna (Christmas Island – limited event)
• Eizen (Huo Mundo)
• Chin Shir
• Ichigo (Boss Island)
• Strongest in History (Shinjuku Island)
• Strongest of Today (Shinjuku Island)
• Remura (Slime Island)
• Moka (Valentine Island – limited event)
• Gilgamesh (Boss Island)

There is also a small chance to obtain Dungeon Keys from chests. Because keys are not guaranteed drops, farming multiple bosses increases your chances.

Step 2: Clear the Rune Dungeon

The Rune Dungeon contains:

• 15 Waves
• Enemies including Raiders, Commanders, Black Knights, and Knights

Difficulty options:

• Easy
• Medium
• Hard
• Extreme

Higher difficulty = Better drop rates.

If your build can handle Hard or Extreme, always choose the higher setting for improved mythical rune chances.

Best Runes to Aim For

If your goal is maximum combat power:

• Inferno Rune (Top DPS)
• Blood Rune (Strong damage over time)
• Wrath Rune (Best raw multiplier)

If you need durability:

• Guardian Rune

Everything else is situational—but still better than running no rune at all.

Runes may not be mandatory in Sailor Piece, but they dramatically improve your performance in boss fights, PvP, and dungeon clears. High-tier runes like Inferno, Blood, and Wrath can completely transform your build. Focus on farming Dungeon Keys from World Bosses, push higher Rune Dungeon difficulties whenever possible, and prioritize S-tier options for the strongest results. If you’re aiming to compete at endgame level, upgrading and optimizing your rune setup isn’t optional—it’s essential.