In Neverness to Everness (NTE), builds are not only defined by characters and weapons, but also by Cartridges. These are one of the most important progression systems in the game, acting as core modifiers that enhance damage, survivability, and team synergy. Choosing the right Cartridge set can completely change how a character performs, especially in high-end content where optimization matters. This guide breaks down every major S-Rank Cartridge in Version 1.0 and the best characters to pair with them.
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What Are Cartridges in NTE?
Cartridges function as set bonuses that activate powerful effects when equipped in combinations (usually 2-piece and 4-piece sets). They are designed to:
- Boost specific damage types
- Strengthen character identity
- Enable team synergy effects
- Scale late-game performance
A properly matched Cartridge set often matters just as much as the character itself.
All NTE Cartridges and Best Character Pairings
Lost Radiance
- 2-Piece: Cosmos DMG +10%
- 4-Piece: Ignores 25% enemy DEF for 20s after Ultimate
Best Characters:
- Chiz
- Zero (Esper)
- Edgar
- Hotori
A top-tier DPS set for Cosmos characters. The DEF ignore effect makes it extremely strong in both boss fights and endgame content.
Speedy Hedgehog
- 2-Piece: Charge Efficiency +12%
- 4-Piece: Team ATK +15% after Ultimate
Best Characters:
- Sakiri
- Haniel
- Adler
A support-focused set designed for team-wide buffs. Sakiri is one of the best users since she can consistently trigger the ATK boost.
Devil’s Blood: Curse
- 2-Piece: Psyche DMG +10%
- 4-Piece: +18% DMG (36% vs Nova/Stain targets)
Best Characters:
- Haniel
- Aurelia
- Fadia
One of the strongest Psyche sets in the game. It becomes significantly more powerful in teams that trigger Nova or Stain effects.
Fireflies and the Forest
- 2-Piece: Anima DMG +10%
- 4-Piece: Crit DMG stacking up to 56%
Best Characters:
- Nanally
- Jiuyuan
- Mint
A scaling-heavy DPS set that rewards fast multi-hit characters. Nanally and Jiuyuan benefit the most due to rapid stack generation.
Street Boxer
- 2-Piece: Lakshana DMG +10%
- 4-Piece: Crit Chance +14% (doubles with Remora/Stain)
Best Characters:
- Hathor
- Skia
A critical hit-focused set designed for aggressive damage dealers. Hathor especially gains strong value from the increased Crit Chance.
Diabolos
- 2-Piece: Chaos DMG +10%
- 4-Piece: Ignores Chaos RES (up to 24% with reactions)
Best Characters:
- Daffodill
- Lacrimosa
A mandatory set for Chaos-based DPS. It helps bypass enemy resistance, making it extremely effective in late-game encounters.
Crimson: Twin Butterflies
- 2-Piece: Incantation DMG +10%
- 4-Piece: ATK stacking from Incantation hits
Best Characters:
- Baicang
- Sakiri
- Adler
Best suited for Incantation users. Baicang gains the most value thanks to his damage-over-time and skill-based kit.
Tiny Big Adventure
- 2-Piece: HP +10%
- 4-Piece: Max HP stacking when taking damage
Best Characters:
- Fadia
A highly specialized defensive set. It works almost exclusively for Fadia, whose kit scales heavily with Max HP and damage absorption.
Shadow Creed
- 2-Piece: ATK +10%
- 4-Piece: +25% ATK after Skill usage
Best Characters:
- Zero (Esper)
- Jiuyuan
- Sakiri
A strong burst-oriented set for sub-DPS characters. Works best with short cooldown skills for frequent ATK buffs.
Quiet Manor
- 2-Piece: Mental DMG +10%
- 4-Piece: Basic Attack stacking Mental DMG bonus
Best Characters:
- Fadia
While designed for Mental builds, the stacking mechanic is inconsistent, making it harder to fully optimize compared to other sets.
Thea’s Night Tavern
- 2-Piece: HP +10%
- 4-Piece: Healing Bonus +20%
Best Characters:
- Edgar
A straightforward healing set. It maximizes sustain and makes Edgar a reliable support in longer fights.
Kingdom’s Guard
- 2-Piece: DEF +15%
- 4-Piece: Shield effectiveness +20%
Best Characters:
- Adler
A defensive support set designed to strengthen shields and improve team survivability during rotations.
How to Choose the Right Cartridge Set
When building your team in NTE, focus on these priorities:
- Match Cartridge damage type with character type
- Use support sets only on true support units
- Prioritize synergy over raw stats
- Build around team reactions like Nova, Stain, or Chaos scaling
A good Cartridge setup can easily outperform raw character upgrades if used correctly.
Cartridges are one of the most important systems in Neverness to Everness, especially once you start pushing higher difficulty content. While characters define your playstyle, Cartridges define how far that playstyle can scale. The strongest setups usually come from combining high-synergy DPS sets like Lost Radiance or Fireflies and the Forest with properly matched characters who can trigger their effects consistently. Once you understand these pairings, building optimized teams becomes much easier and far more efficient.